Sir Martin Moore-Bick, the retired judge chosen by Prime Minister Theresa May to lead the inquiry, will give his address at the Grand Connaught Rooms in central London.
The former Court of Appeal judge will not take questions following the hearing, which is expected to last around 45 minutes.
Survivors and victims’ families will be able to watch live on a screen in Notting Hill Methodist Church, where they are likely to be listening intently to the language and tone of Sir Martin’s opening.
The chairman faced anger from the community in a series of public meetings designed to help shape the terms of reference but, once these were announced, the inquiry was criticised for excluding an examination of wider social housing policy.
Campaigners had pressed for the probe to scrutinise the...