The American, 37, will overtake sister Serena’s record – set when she was 35 at the Australian Open in January – by winning her sixth SW19 title.
“I don’t think about my age,” Williams told BBC Sport. “It is not a factor.”
Spain’s Muguruza, 23, is aiming for her first Wimbledon triumph after losing to Serena in the 2015 final.
“My mind is more equipped this...